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Wednesday, February 23, 2005A compound in the common daisy-like plant feverfew kills human leukemia stem cells and could form the basis for newer, more effective drugs for the disease.

American researchers at the University of Rochester Medical Center in New York say that it could take months to develop a useable drug from the compound, parthenolide.

However, they are working to do so with chemists at the University of Kentucky who have identified a water-soluble molecule with the same properties. The US National Cancer Institute has also accepted the work into its rapid access program, which aims to speed experimental drugs into human clinical trials.

“This research is a very important step in setting the stage for future development of a new therapy for leukemia,” says Rochester researcher Craig Jordan. “We have proof that we can kill leukemia stem cells with this type of agent, and that is good news.”

Parthenolide appears to target the roots of myeloid leukemia, stem cells, while current treatments including the relatively new drug Gleevec don’t. So, “You’re pulling the weed without getting to the root,” says Jordan.

Used for centuries to fight fevers, inflammation and arthritis, feverfew earned interest from the Rochester researchers after other scientists showed that it could prevent skin cancer in animal models.

So the researchers investigated how a concentrated form of the plant component parthenolide would affect leukemia cells and normal cells.

Comparing the impact of parthenolide to the common chemotherapy drug cytarabine, they found that parthenolide selectively killed leukemia cells while sparing normal cells better.

While the findings suggest that parthenolide is a good starting point for new drugs, people with leukemia aren’t being encouraged to take high doses of feverfew as they could not take enough of the remedy to halt the disease.

The research is reported in the journal Blood.

Saturday, June 30, 2007

Glasgow International Airport in Renfrewshire, Scotland was evacuated after a green Jeep Cherokee struck the airport’s terminal building and burst into flames at 1511 BST.

An eyewitness told the BBC that “[A] man was on fire.” All flights are grounded, and two men have been arrested and the United Kingdom has raised the national threat level to “critical” which means another terror attack is imminent.

Eyewitnesses described a Jeep speeding toward the building with flames coming out from underneath. They also reported seeing two Asian men in the car, one of whom was on fire.

The BBC quoted an eyewitness as saying that two attempts were made to ram the Jeep through the wall, and that the passenger was holding a lit Molotov Cocktail and made several attempts to throw the bottle.

The Strathclyde Police Chief announced that the event is being linked to the earlier attempted car bombings in London, and as such is being treated as a terrorist investigation.

Eyewitnesses are now saying that one of the two men was pouring bottles of petrol into the car’s interior and onto himself, before running from the car, on fire, into the main terminal building. Witnesses have also reported that gas cylinders were removed by bystanders from the burning vehicle.

According to the BBC, the driver of the vehicle put up a violent struggle before being overpowered by the police and public. One person who tackled him was Stephen Clarkson, a member of the public.

Richard Gray, an eyewitness to the event, stated “There was an Asian guy who was pulled out of the car by two police officers.”

Seven people have been taken to local hospitals with injuries.

Police said that this incident was a deliberate attempt and not a road accident. Officials have also said that the incident is connected to earlier attempted car bombings in London the day before.

Two people have been arrested, one of whom was badly burned. Seven known casualties, including the Asian male have been taken to the Royal Alexandra Hospital, Paisley.

While the suspect was being treated in the hospital, a suspect device was discovered in the hospital, resulting in the partial evacuation of the building while the device was moved to a safe area. This object later turned out to be mundane, although initial reports believed it to be a suicide belt.

The BBC announced that the Prime Minister is being kept fully informed. He chaired a meeting of Civil Contingencies Committee (COBRA) at 1900 (BST), after which the Home Secretary, Jacqui Smith, announced that the national threat level been elevated from “Severe” to “Critical”, meaning another attack is expected “imminently.”

Officials at Edinburgh Airport have said that all cars are being turned away from the airport, and at Heathrow in London, passengers are being advised not to bring private cars near to the terminal buildings. Some passengers were kept waiting in planes while the area was secured.

The first bomber, who was taken to Govan high security prison, has now been interviewed, though no further statements from Strathclyde police have been forthcoming. The second bomber, who was taken to the Royal Alexandria hospital in Paisley, is listed in critical condition tonight, and is being kept under 24-hour guard.

2,300 passengers who were due to set off from Glasgow Airport today have been driven by coach to a conference centre, where a reception area has been set up for them.

Two people were arrested by The Metropolitan Police Anti-Terrorist Branch on the M6 motorway in Cheshire in connection with the Glasgow International Airport attack and attempted London car bombings.

The Prime Minister Gordon Brown is expected to hold another COBRA meeting with other members of the Cabinet today. This will be the fifth COBRA meeting in 48 hours.

Thursday, August 6, 2009

American film director John Hughes, noted for such movies as Sixteen Candles, Pretty in Pink and The Breakfast Club, died Thursday due to a heart attack.

A statement, released by his representative, said that he experienced the heart attack while on a morning stroll in Manhattan, New York. Hughes was born on February 18, 1950 in Michigan. He started his career as an advertising copywriter in Chicago. By the end of the 1970s he was a frequent contributor to the National Lampoon magazine.

In the 1990s, he made the Home Alone series, which became a box office sensation and turned Macaulay Culkin into a star.

In recent years, Hughes stepped back from the movie industry to spend more time with his family. He is survived by his wife of 39 years, Nancy, two sons and four grandchildren.

Tuesday, February 13, 2007

In Vancouver, a 20-year urban success story may yet have a sad ending. The city’s downtown population has doubled to 80,000 in the last 20 years thanks to Vancouver’s “Living First” policy – a planning strategy that favors residential development over commercial. And planners are expecting the population to reach more than 120,000 by 2030. But while downtown booms with people, business is busting. The International Herald Tribune reports that the city’s recently-released jobs and land-use study is estimating that downtown Vancouver may run out of commercial and office space within 5 years.

The ‘Vancouver problem’ is one that many cities in the United States could only hope to have. On the contrary, much effort has been put into bringing residential life back into the city centres. In Los Angeles, San Diego, Miami, and Washington, D.C. there has been a condominium boom in recent years, but these cities are far from the situation Vancouver faces now.

To counter the trend in Vancouver, planners are proposing changes to the city’s zoning regulations, including the passage of more lenient building height restrictions. But because residential developments are so much more profitable than commercial and office space, some public officials are proposing offering better incentives to the developers willing to build commercial. Another option is to expand the moratorium that was placed on new housing development in the central business district two years ago.

Translink is currently involved in a major expansion of the 49.5 km (30.8 mi) Skytrain system centred on downtown Vancouver. Construction of the Canada and Evergreen lines is underway. The former will be complete in 2009, and the latter in 2011.

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Monday, July 11, 2005

Thomas Charles Damron, aged 22, was charged in the death of 18 year old Kathryn Sutherland, killed Saturday afternoon in a four-car crash Saturday afternoon near Romeo, Michigan.

Damron, arraigned Monday afternoon, was charged with operating a vehicle with the presence of drugs causing death, possession of marijuana, and negligent homicide. Preliminary investigations indicate that Damron crashed into the rear of another vehicle starting a chain reaction that ultimately led to still another car crossing into the westbound lane where it struck the victim’s car.

Kathryn Sutherland died after she was airlifted to the University of Michigan Medical Center.

Thursday, January 8, 2009

Electronic Gaming Monthly is now dead. EGM was one issue away from its 20th anniversary in February 2009. An internal email leaked to industry website Gamasutra on Tuesday revealed that EGM was to be closed following the acquisition of the online element of the 1UP network by competitor Hearst Corporation‘s UGO Entertainment and that the January 2009 issue (with Wolverine on the cover) would be the final printed issue of the iconic magazine. Ziff Davis‘s sale, brokered by GCA Savvian Advisors also includes Mycheats.com, Gametab.com, and GameVideos.com. Hearst Interactive is the owner and operator of UGO Entertainment.

According to CEO Jason Young, the court proceedings help Ziff Davis “pay down debt and shift our full focus to our core PCMag Digital Network Business.” Davis had been focusing on PCMag Digital Network. As a result, around 30 employees of Ziff Davis’ Game Group, including EGM Magazine’s staff, 1UP Network’s web staff, podcast and video producers lost their jobs. A UGO spokesman explained that “the reality is that UGO Entertainment is saving over 25 jobs, the company is retaining a core group of editorial all-star performers.” Ziff Davis Holdings Inc (ZFDH.PK), which publishes EGM and about 15 Web sites, obtained Manhattan, New York Court Judge Burton Lifland’s approval of a reorganization plan under Chapter 11, Title 11, United States Code. It was able, therefore, to emerge from its duly filed March bankruptcy protection petition.

UGO Entertainment CEO J Moses left a note on EGM’s gaming legacy, saying, “since we started UGO 11 years ago, we have served the gamer community and built a world-class online publishing platform.” Ziff Davis Media CEO Jason Young further noted: “We believe this is a smart transaction for Ziff Davis Media that places these market leading assets and teams in a great environment poised for further success. The transaction allows us to pay down debt and shift our full focus to our core PCMag Digital Network business. We thank our 1UP team members for their contributions and wish them the best of success into the future.” In July 2007, Hearst acquired the 11-year-old UGO Networks (Hearst Interactive) for an estimated price of $100 million. Established in 1998 by CEO J Moses, UGO is an online site targeting men aged 18 to 34.

J Moses stated categorically that his company just saved 1UP and UGO never tried to acquire EGM. “Closing EGM has absolutely nothing to do with UGO. We have just hired 24 people and have expanded UGO by 33 percent, because our business is robust and growing. We only wanted to buy 1UP and related sites. That was our interest as a dot-com company and that’s all we’ve ever been for 11 years.” Sam Kennedy, editorial director of 1UP, further explained that Ziff Davis was insolvent and 1UP was not financially healthy. “The reality of the market was that no company, including UGO, was willing to sustain 1UP as it was so the cuts were very painful but necessary to the survival of 1UP,” he added.

Electronic Gaming Monthly, which has been synonymous to video games for generations of gamers, was an American consumer video game magazine mainstay. It was published by Ziff Davis as part of the 1UP Network and released 12 issues a year (and an occasional extra “13th” issue for the Christmas season, also known as the “Smarch” issue, a reference to an episode of The Simpsons). As ZD’s sole print magazine, EGM, a stalwart of the videogame industry and dubbed the New York Times of games journalism, has been losing money. The 20-year-old publication had 236 issues total, since its debut in 1989.

In 2008, the company closed 27-year Games for Windows Magazine, or Computer Gaming World. In late 2006, Ziff-Davis also shuttered its Official U.S. PlayStation Magazine, while its Xbox-focused XBN and Electronics Boutique in-store mag GMR were terminated in 2004. EGM’s February issue, which is completed, will only be available digitally. Print publications have been suffering for years now, due to the global economic meltdown.

Tuesday, September 20, 2005

Wireless provider Sprint announced today, that they would be working with RealNetworks to launch a streaming music service, for Sprint wireless customers, called Rhapsody Radio.

The service will allow users to listen to podcasts and six streaming radio stations (rap, hip-hop hits, alternative, country, ’70s, and music news) from their mobile phone. Users will be able to listen to live broadcasts of those stations over their cellular connection. For a monthly subscription fee of $6.95, users will also have unlimited access to commercial-free radio broadcasts. Selected streaming podcasts from KCRW, Santa Monica 89.9 FM, and National Public Radio’s Southern California station will also be available. A special Beats N Breaks stream is also available. Beats N Breaks provides background music from hip-hop songs for users to rap with.

Rhapsody Radio service requires a Sanyo MM-7400, Sanyo MM-5600, Sanyo MM-8300, Samsung IP-A790, Samsung MM-A800, Samsung MM-A880 or an LG MM-535 mobile phone. Customers are able to order directly from their phones, with the charge appearing on their next bill.

Many analysts predicted the introduction of music services by other wireless providers after Apple recently introduced the Motorola ROKR. The Motorola ROKR comes with a version of the iTunes software which allows users to listen to up to 100 songs on their phone. Service for this phone in the USA is provided by Cingular Wireless.